Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Krt1  keratin 1   (Synonyms: Krt-2.1, Krt2-1)
Results	Reference
1	J:233601 Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP, Harwood CA, Byrne C, O'Shaughnessy RF, Bergamaschi D, Constitutive Autophagy and Nucleophagy during Epidermal Differentiation. J Invest Dermatol. 2016 Jul;136(7):1460-70
1	J:76477 Andl T, Reddy ST, Gaddapara T, Millar SE, WNT Signals Are Required for the Initiation of Hair Follicle Development. Dev Cell. 2002 May;2(5):643-53
1	J:114702 Blanpain C, Lowry WE, Pasolli HA, Fuchs E, Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 2006 Nov 1;20(21):3022-35
1	J:316303 Camacho Leal MDP, Costamagna A, Tassone B, Saoncella S, Simoni M, Natalini D, Dadone A, Sciortino M, Turco E, Defilippi P, Calautti E, Cabodi S, Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation. Cell Commun Signal. 2018 Nov 3;16(1):73
1	J:171221 Croyle MJ, Lehman JM, O'Connor AK, Wong SY, Malarkey EB, Iribarne D, Dowdle WE, Schoeb TR, Verney ZM, Athar M, Michaud EJ, Reiter JF, Yoder BK, Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development. 2011 May;138(9):1675-85
1*	J:129949 Cui CY, Kunisada M, Esibizione D, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D, Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet. 2007 Nov 1;16(21):2583-90
1	J:306061 Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H, High proliferation and delamination during skin epidermal stratification. Nat Commun. 2021 May 28;12(1):3227
1	J:177724 Danussi C, Petrucco A, Wassermann B, Pivetta E, Modica TM, Belluz Ldel B, Colombatti A, Spessotto P, EMILIN1-alpha4/alpha9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J Cell Biol. 2011 Oct 3;195(1):131-45
1	J:67155 Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J, Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development. 2001 Feb;128(4):513-25
1	J:195087 Francis JC, Thomsen MK, Taketo MM, Swain A, beta-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma. PLoS Genet. 2013 Jan;9(1):e1003180
1	J:166833 Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI, The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell. 2010 Nov 16;19(5):727-39
1	J:235678 Grisanti L, Revenkova E, Gordon RE, Iomini C, Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway. Development. 2016 Jun 15;143(12):2160-71
1	J:117334 Gritli-Linde A, Hallberg K, Harfe BD, Reyahi A, Kannius-Janson M, Nilsson J, Cobourne MT, Sharpe PT, McMahon AP, Linde A, Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell. 2007 Jan;12(1):99-112
1	J:258233 Guo D, Yuan Z, Ru J, Gu X, Zhang W, Mao F, Ouyang H, Wu K, Liu Y, Liu C, A Spatiotemporal Requirement for Prickle 1-Mediated PCP Signaling in Eyelid Morphogenesis and Homeostasis. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):952-966
1	J:196827 Hahn N, Dietz CT, Kuhl S, Vossmerbaeumer U, Kroll J, KLEIP deficiency in mice causes progressive corneal neovascular dystrophy. Invest Ophthalmol Vis Sci. 2012 May;53(6):3260-8
1	J:115995 Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E, Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell. 2006 Aug 11;126(3):597-609
1	J:140203 Hwang J, Mehrani T, Millar SE, Morasso MI, Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development. 2008 Sep;135(18):3149-59
1*	J:99529 Hwang M, Kalinin A, Morasso MI, The temporal and spatial expression of the novel Ca(++)-binding proteins, Scarf and Scarf2, during development and epidermal differentiation. Gene Expr Patterns. 2005 Aug;5(6):801-8
1*	J:97304 Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD, Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005 Mar 25;120(6):843-56
1	J:135131 Kashiwagi M, Morgan BA, Georgopoulos K, The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007 Apr;134(8):1571-82
1	J:228858 Kist R, Watson M, Crosier M, Robinson M, Fuchs J, Reichelt J, Peters H, The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. PLoS Genet. 2014 Oct;10(10):e1004709
1	J:208053 Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ, Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering. J Pathol. 2014 Apr;232(5):541-52
1	J:244349 Kousa YA, Moussa D, Schutte BC, IRF6 expression in basal epithelium partially rescues Irf6 knockout mice. Dev Dyn. 2017 Sep;246(9):670-681
1	J:114152 Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R, Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
1	J:332513 Laporte E, De Vriendt S, Hoekx J, Vankelecom H, Interleukin-6 is dispensable in pituitary normal development and homeostasis but needed for pituitary stem cell activation following local injury. Front Endocrinol (Lausanne). 2022;13:1092063
1	J:54224 Lee D, Prowse DM, Brissette JL, Association between mouse nude gene expression and the initiation of epithelial terminal differentiation. Dev Biol. 1999 Apr 15;208(2):362-74
1	J:180119 Lee DW, Zhao X, Yim YI, Eisenberg E, Greene LE, Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell. 2008 Jul;19(7):2766-76
1	J:320850 Lessard JC, Kalinin A, Bible PW, Morasso MI, Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice. Exp Dermatol. 2015 Jan;24(1):55-7
1	J:274466 Li G, Ye Z, Shi C, Sun L, Han M, Zhuang Y, Xu T, Zhao S, Wu X, The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. Sci Rep. 2017 Apr 4;7:45401
1	J:154022 Lopez RG, Garcia-Silva S, Moore SJ, Bereshchenko O, Martinez-Cruz AB, Ermakova O, Kurz E, Paramio JM, Nerlov C, C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. Nat Cell Biol. 2009 Oct;11(10):1181-90
1	J:116504 Matsui T, Kinoshita-Ida Y, Hayashi-Kisumi F, Hata M, Matsubara K, Chiba M, Katahira-Tayama S, Morita K, Miyachi Y, Tsukita S, Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation. J Biol Chem. 2006 Sep 15;281(37):27512-25
1	J:236802 Muroyama A, Seldin L, Lechler T, Divergent regulation of functionally distinct gamma-tubulin complexes during differentiation. J Cell Biol. 2016 Jun 20;213(6):679-92
1	J:118511 Nakamura M, Matzuk MM, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, Werner S, Paus R, Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J. 2003 Mar;17(3):497-9
1	J:155012 Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E, Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet. 2009 Oct;41(10):1068-75
1	J:124280 Nieuwenhuis E, Barnfield PC, Makino S, Hui CC, Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev Biol. 2007 Aug 15;308(2):547-60
1*	J:190629 Niimori D, Kawano R, Felemban A, Niimori-Kita K, Tanaka H, Ihn H, Ohta K, Tsukushi controls the hair cycle by regulating TGF-beta1 signaling. Dev Biol. 2012 Dec 1;372(1):81-7
1	J:207286 Nowak JA, Polak L, Pasolli HA, Fuchs E, Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell. 2008 Jul 3;3(1):33-43
1	J:226044 Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R, MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. Elife. 2015;4
1	J:149319 Romano RA, Ortt K, Birkaya B, Smalley K, Sinha S, An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One. 2009;4(5):e5623
1	J:168262 Romano RA, Smalley K, Liu S, Sinha S, Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha. Development. 2010 May;137(9):1431-9
1	J:323229 Rosendahl AH, Monnius M, Laitala A, Railo A, Miinalainen I, Heljasvaara R, Maki JM, Myllyharju J, Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. J Biol Chem. 2022 Mar 2;298(4):101787
1	J:200244 Roth W, Kumar V, Beer HD, Richter M, Wohlenberg C, Reuter U, Thiering S, Staratschek-Jox A, Hofmann A, Kreusch F, Schultze JL, Vogl T, Roth J, Reichelt J, Hausser I, Magin TM, Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci. 2012 Nov 15;125(Pt 22):5269-79
1	J:131056 Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Maatta A, Watt FM, Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol. 2007 Dec 31;179(7):1599-612
1*	J:157895 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
1	J:192592 Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C, BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
1	J:212275 Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X, Pygo2 regulates beta-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10215-20
1	J:194779 Tao J, Koster MI, Harrison W, Moran JL, Beier DR, Roop DR, Overbeek PA, A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis. PLoS One. 2012;7(11):e50634
1	J:181138 Taylor DK, Bubier JA, Silva KA, Sundberg JP, Development, structure, and keratin expression in C57BL/6J mouse eccrine glands. Vet Pathol. 2012 Jan;49(1):146-54
1	J:144091 Tinkle CL, Pasolli HA, Stokes N, Fuchs E, New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15405-10
1	J:163216 Van Keymeulen A, Mascre G, Youseff KK, Harel I, Michaux C, De Geest N, Szpalski C, Achouri Y, Bloch W, Hassan BA, Blanpain C, Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol. 2009 Oct 5;187(1):91-100
1	J:100563 Vauclair S, Nicolas M, Barrandon Y, Radtke F, Notch1 is essential for postnatal hair follicle development and homeostasis. Dev Biol. 2005 Aug 1;284(1):184-93
1	J:100131 Vidal VP, Chaboissier MC, Lutzkendorf S, Cotsarelis G, Mill P, Hui CC, Ortonne N, Ortonne JP, Schedl A, Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol. 2005 Aug 9;15(15):1340-51
1	J:86392 Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M, Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003 Nov;35(3):238-45
1	J:338452 Wang D, Li H, Chandel NS, Dou Y, Yi R, MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters. Nat Commun. 2023 Jul 21;14(1):4404
1	J:201587 Wang D, Zhang Z, O'Loughlin E, Wang L, Fan X, Lai EC, Yi R, MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol. 2013 Oct;15(10):1153-63
1	J:287165 Wang J, Lee JE, Riemondy K, Yu Y, Marquez SM, Lai EC, Yi R, XPO5 promotes primary miRNA processing independently of RanGTP. Nat Commun. 2020 Apr 15;11(1):1845
1	J:108855 Xu H, Delling M, Jun JC, Clapham DE, Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-635
1	J:330323 Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y, Komatsu Y, Enhanced BMP signaling through ALK2 attenuates keratinocyte differentiation. Biochem Biophys Res Commun. 2022 Nov 12;629:101-105
1	J:229029 Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M, The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. 2015 Oct 19;212(11):1901-19
1	J:310840 Yang GN, Ahangar P, Strudwick XL, Kopecki Z, Cowin AJ, Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells. Int J Mol Sci. 2021 Jul 30;22(15)
1	J:106792 Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, Fuchs E, Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006 Mar;38(3):356-62
1	J:169106 Zhang H, Pasolli HA, Fuchs E, Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2270-5
1	J:262458 Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR, Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One. 2016;11(8):e0161465
1*	J:293298 Zhang M, Wang X, Guo F, Jia Q, Liu N, Chen Y, Yan Y, Huang M, Tang H, Deng Y, Huang S, Zhou Z, Zhang L, Zhang L, Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development. Theranostics. 2019;9(17):5065-5084
1	J:141138 Zhang Y, Burgess D, Overbeek PA, Govindarajan V, Dominant inhibition of lens placode formation in mice. Dev Biol. 2008 Nov 1;323(1):53-63